专利名称：Intermediates and improved processes for
the preparation of neplanocin A
发明人：Naoyuki Yoshida,Kunio Ogasawara申请号：US10369532申请日：20030221
公开号：US20030157697A1公开日：20030821
摘要：Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0]dec-8-ene, which are useful for thesynthesis of neplanocin A having strong antitumor activity. Improved processes for thepreparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reactionof the above intermediate.
申请人：CHISSO CORPORATION
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