Reducing carbohydrate derivatives of adamantane am

专利名称：Reducing carbohydrate derivatives of

adamantane amines, and synthesis andmethods of use thereof

发明人：Sebastian P. Assenza,Nanzhu Shen,Salvatore

Iacono,Yuriy B. Kalyan,Peter Viski,MatthewRonsheim

申请号：US11304977申请日：20051214

公开号：US20060211650A1公开日：20060921

摘要：The present invention relates to reducing carbohydrate derivatives ofadamantane amines of Formula A or pharmaceutically acceptable salts, solvates orderivatives thereof, wherein R, R, R, and Rare together or separately H, F, methyl or loweralkyl, alkenyl, or alkynyl groups, and Z is derived from a mono-, di-, oligo-, or poly-saccharide that originally had an aldehyde carbonyl group. The present invention alsorelates to processes for the preparation of such adamantane amine derivatives, and usesof such derivatives. The compounds of the present invention are useful in the treatmentof infections caused by Gram positive or Gram negative bacteria.

申请人：Sebastian P. Assenza,Nanzhu Shen,Salvatore Iacono,Yuriy B. Kalyan,PeterViski,Matthew Ronsheim

地址：Fort Salonga NY US,Medford NY US,Kings Park NY US,Staten Island NYUS,Arlington VA US,Port Jefferson NY US

国籍：US,US,US,US,US,US

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