Assays, methods and means

专利名称：Assays, methods and means

发明人：Patrick Henry Maxwell,Christopher William

Pugh,Peter John Ratcliffe,ChristopherJoseph Schofield

申请号：US126993申请日：20100112

公开号：US20100272726A1公开日：20101028

摘要：A novel class of hydroxylases is described having the amino acid sequence ofSEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylationactivity. The polypeptides of the invention have in particular prolyl hydroxylase activity.An assay method monitors the interaction of the HIF hydroxylase with a substrate.Modulators of HIF hydroxylase are provided for use in the treatment of a conditionassociated with increased or decreased HIF levels or activity or for the treatment of acondition where it is desirable to modulate HIF levels or activity.

申请人：Patrick Henry Maxwell,Christopher William Pugh,Peter JohnRatcliffe,Christopher Joseph Schofield

地址：Oxford GB,Oxford GB,Oxford GB,Oxford GB

国籍：GB,GB,GB,GB

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