IMPROVED PROCESS FOR THE PREPARATION OF PHENETHYLA

专利名称：IMPROVED PROCESS FOR THE

PREPARATION OF PHENETHYLAMINEDERIVATIVES

发明人：Soni, Rohit, Ravikant,Koftis,

Theocharis,Panagiotidis,

Theodoros,Georgopoulou, Ioanna

申请号：EP07722748.6申请日：20070109公开号：EP2121574A1公开日：20091125

摘要：The present invention relates to an improved process for the preparation ofessentially pure Venlafaxine Hydrochloride. Particularly, the process for the preparationof Venlafaxine Hydrochloride comprises the following steps: i) Preparation of 1-[Cyano-1-(4-methoxyphenyl)methyl]cyclohexanol, ii) Preparation of crude Venlafaxine

Hydrochloride by reduction of 1-[Cyano-1-(4-methoxyphenyl)methyl]cyclohexanol withAlkali metal borohydride and Lewis acid and subsequent conversion to Venalfaxinehydrochloride with formic acid and paraformaldehyde and finally iii) Purification of crudeVenlafaxine Hydrochloride.

申请人：Pharmathen S.A.

地址：6, Dervenakion str. Pallini, Attikis 15351 GR

国籍：GR

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