专利名称：Novel monoclonal antibody to human
carcinomas
发明人：Hellstrom, Ingegerd,Hellstrom, Karl Erik申请号：EP89403631.8申请日：19891222公开号：EP0375562A2公开日：19900627
摘要：The present invention relates to a novel monoclonal antibody reactive withhuman carcinoma cells. More particularly, the antibody of the invention is a monoclonalantibody reactive with a glycolipid cell membrane antigen on the surface of humancarcinomas. The antibody displays a high degree of selectivity for carcinoma cells,showing a low degree of reactivity with certain normal human cells and no detectablereactivity with other types of tumors such as lymphomas, sarcomas or melanomas. Inaddition, the antibody of the invention is capable of internalizing within the carcinomacells to which it binds and is therefore particularly useful for therapeutic applications, forexample, as the antibody component of antibody-drug or antibody-toxin conjugates.
申请人：ONCOGEN LIMITED PARTNERSHIP
地址：3005 First Avenue Seattle, WA 98121 US
国籍：US
代理机构：Warcoin, Jacques
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